Role of tumor-associated macrophages in human malignancies: friend or foe?

International Trends in Immunity

IL-15 is a member of the family of IL-2 cytokines. This family of cytokines activates signaling pathways leading to cellular activation, proliferation and survival. IL-15 exhibits broad activity and induces the differentiation and proliferation of NK, T and B cells. Furthermore, IL-15 protects T-effector cells from the action of T Regulatory cells and reverses tolerance to tumor associated anti...

Kant: Friend or Foe of the Believer? Plantinga and Other American Christian Responses to Kant's Epistemology

P157: Periostin Recruits Tumor Associated Macrophages in Glioblastoma Multiform

Glioblastoma multiform (GBM) is the most common and lethal type of primary brain tumors with high rates of morbidity and mortality. Treatment options are limited and ineffective in most of the cases. Epidemiological studies have shown a link between inflammation and glioma genesis.  In addition, at the molecular level, pro-inflammatory cytokines released from activated microglia can increa...

Apocrine Metaplasia in Intraductal Papilloma with Foci of DCIS: A Friend or Foe?

Malignant papillary neoplasms of the breast comprise a number of microscopically distinct lesions, where apocrine metaplasia is commonly found in papillomas compared to other papillary lesions including papillary carcinomas. However, association of apocrine metaplasia in papilloma with Ductal Carcinoma in Situ (DCIS) is not very well defined. The lesions with apocrine metaplasia are not only di...

Flowcytometric Analysis of Tumor Associated Macrophages in Invasive Ductal Carcinoma of Breast

Background: Invasive ductal carcinoma is the most common type of breast cancer in Iran. Impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood. It is believed that infiltrated immune cells, especially macrophages, may provide help for tumor cell growth and metastasis.   Objective: To analyze the status of tumor as...